More Filters. View 1 excerpt. Regulatory asymmetry in the negative single-input module network motif: Role of network size, growth rate and binding affinity. Tunability enhancement of gene regulatory motifs through competition for regulatory protein resources. Highly Influenced. View 4 excerpts, cites background and results. Stability and structural properties of gene regulation networks with coregulation rules.
Journal of theoretical biology. Computer Science, Physics. View 2 excerpts, cites background. Substrate concentration effect on gene expression in genetic circuits with additional positive feedback.
Science China Technological Sciences. In gene regulatory networks, gene regulation loops often occur with multiple positive feedback, multiple negative feedback and coupled positive and negative feedback forms. In above gene regulation … Expand. Hill kinetics as a noise filter: the role of transcription factor autoregulation in gene cascades. Physical chemistry chemical physics : PCCP. Inherent regulatory asymmetry emanating from network architecture in a prevalent autoregulatory motif. View 3 excerpts, cites background.
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Log In Sign Up. Download Free PDF. Metrics details. Systems biology is the study of complex gene networks, protein networks, metabolic networks and so on. The goal is to understand the design principles of living systems.
That depends. Some people focus on networks at the 'omics'-scale: whole genomes, proteomes, or metabolomes. Please note: In order to keep Hive up to date and provide users with the best features, we are no longer able to fully support Internet Explorer. The site is still available to you, however some sections of the site may appear broken.
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Praise for the first edition Alon provides nicely written appendices to explain the basic mathematical and biological concepts clearly and succinctly without interfering with the main text. He starts with a mathematical description of transcriptional activation and then describes some basic transcription-network motifs patterns that can be combined to form larger networks.
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An Introduction to Systems Biology: Design Principles of Biological Circuits builds a solid foundation for the intuitive understanding of general principles. It encourages the reader to ask why a system is designed in a particular way and then proceeds to answer with simplified models.
Thorough and accessible, this book presents the design principles of biological systems, and highlights the recurring circuit elements that make up biological networks. It provides a simple mathematical framework which can be used to understand and even design biological circuits. The text avoids specialist terms, focusing instead on several well-studied biological systems that concisely demonstrate key principles.
There is no official textbook for this course.
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